ea0081oc6.5 | Oral Communications 6: Endocrine-Related Cancer | ECE2022
Gesmundo Iacopo
, Vitale Nicoletta
, Orlando Giulia
, Bertoldo Alessia
, Papotti Mauro
, Deaglio Silvia
, Ghigo Ezio
, Schally Andrew V
, Granata Riccarda
Human malignant pleural mesothelioma (MPM) is a rare but aggressive neoplasm, arising from pleural mesothelial cells, generally due exposure to asbestos. Of note, different growth factors and their receptors are involved in the pathogenesis of MPM and resistance to therapy. Chemotherapy with cisplatin (cis) and antifolates, like pemetrexed (PEM), is the first-line treatment for inoperable MPM. Growth hormone-releasing hormone (GHRH), besides stimulating GH secretion in the ant...